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Personnel:Research -Personal- Denis Xavier |
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Denis Xavier
Coordinator, Division of Clinical Trials
Professor & Head of Pharmacology, St. John’s Medical College |
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Unit/Division |
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Division of Clinical Trials
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Research Interests |
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Cardiovascular epidemiology - Acute coronary syndromes, stroke, peri-operative cardiac ischemia |
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Clinical Trials - multi centric trials, Knowledge translational studies |
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Health Policy and Advocacy |
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Degrees |
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MBBS, 1992,St Johns Medical College,Bangalore
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MD, 1997,St Johns Medical College,Bangalore
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MSc (Clinical Epi & Biostatistics) 2010, McMaster University, Canada, 2010 |
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Positions |
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Coordinator- Division of Clinical Trials, SJRI |
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Professor and Head - Department of Pharmacology, SJMC |
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Joint Secretary –St. John’s alumni Association |
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Editor – KYIT – St. John’s Institutional Newsletter 2010 |
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Extramural research positions |
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Principal Investigator, NHLBI- UH – Center of Excellence to counter chronic diseases in developing countries (more details) |
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Principal Investigator, Fogarty International Scholars Site (more details) |
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Principal Investigator, Pfizer Preferred Research Center |
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Principal Investigator – AMEND – an ongoing program to reduce cardiovascular disease in India |
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Member – International Steering Committee and National Coordinator (CREATE, OASIS 5, 6, 7 (CURRENT), 8 (FUTURA), POISE-1, VITATOPS, HOPE-3, ARISTOTLE, AVERROES, RIVAL, RECREATE, MARS, TIPS, INTERSTROKE, VISION, TIPS-K, RELY, RELY-AF, ASPIRE, PALLAS, Wellcome-Trust – TIPS-3) |
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Investigator and National Coordinator (PRoFESS, PEGASUS – TIMI-54, APPRAISE-2, FRIENDS) |
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Member, NHLBI-UH – Research Training Subcommittee |
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Scientific Reviewer- Lancet, European Heart Journal, Indian Council of Medical Research |
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Member- Drugs and Therapeutics Committee, SJMCH |
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Member- European Society of Cardiology - Heart Failure Trialists Committee |
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Awards & Certifications |
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Fellow of the World Heart Federation,Cardiovascular Epidemiology Teaching seminar. |
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HOPE-Canada research scholarship award |
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WHO-CDSCO certification in Good Clinical Practice
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First prize: Poster presentation at INTERHEART International steering committee meeting, Sydney. |
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Recent Publications |
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Xavier D, Pais P, Devereaux PJ, Xie C, Prabhakaran D, Reddy KS, Gupta R, Joshi P, Kerkar P, Thanikachalam S, Haridas KK, Jaison TM, Naik S, Maity AK, Yusuf S; CREATE registry investigators. Treatment and outcomes of acute coronary syndromes in India (CREATE): a prospective analysis of registry data. Lancet. 2008 Apr 26;371(9622):1435-42. PubMed PMID: 18440425. |
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Yusuf S, Pais P, Afzal R, Xavier D, Teo K, Eikelboom J, Sigamani A, Mohan V, Gupta R, Thomas N. Effects of a polypill (Polycap) on risk factors in middle-aged individuals without cardiovascular disease (TIPS): a phase II, double-blind, randomised trial. Lancet. 2009 Apr 18;373(9672):1341-51. Epub 2009 Mar 30. PubMed PMID: 19339045. |
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O'Donnell MJ, Xavier D, Liu L, Zhang H, Chin SL, Rao-Melacini P, Rangarajan S,Islam S, Pais P, McQueen MJ, Mondo C, Damasceno A, Lopez-Jaramillo P, Hankey GJ, Dans AL, Yusoff K, Truelsen T, Diener HC, Sacco RL, Ryglewicz D, Czlonkowska A,Weimar C, Wang X, Yusuf S; INTERSTROKE investigators. Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. Lancet. 2010 Jul 10;376(9735):112-23. |
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O'Donnell MJ, Xavier D, Liu L, Zhang H, Chin SL, Rao-Melacini P, Rangarajan S,Islam S, Pais P, McQueen MJ, Mondo C, Damasceno A, Lopez-Jaramillo P, Hankey GJ, Dans AL, Yusoff K, Truelsen T, Diener HC, Sacco RL, Ryglewicz D, Czlonkowska A,Weimar C, Wang X, Yusuf S; INTERSTROKE investigators. Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. Lancet. 2010 Jul 10;376(9735):112-23. Epub 2010 Jun 17. PubMed PMID: 20561675. |
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Steg PG, Jolly SS, Mehta SR, Afzal R, Xavier D, Rupprecht HJ, López-Sendón JL, Budaj A, Diaz R, Avezum A, Widimsky P, Rao SV, Chrolavicius S, Meeks B, Joyner C, Pogue J, Yusuf S. Low-Dose vs Standard-Dose Unfractionated Heparin for Coronary Intervention in Acute Coronary Syndromes Treated With Fondaparinux: The FUTURA/OASIS-8 Randomized Trial. JAMA. 2010 Sep 22;304(12):1339-49. Epub 2010 Aug 31.PMID: 20805623 |
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B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: a randomised, double-blind, parallel, placebo-controlled trial. Lancet Neurol. 2010 Sep;9(9):855-65. Epub 2010 Aug 3. PubMed PMID: 20688574. |
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O'Donnell M, Xavier D, Diener C, Sacco R, Lisheng L, Zhang H, Pias P, Truelsen T, Chin SL, Rangarajan S, Devilliers L, Damasceno A, Mondo C, Lanas F, Avezum A, Diaz R, Varigos J, Hankey G, Teal P, Kapral M, Ryglewicz D, Czlonkowska A, Skowronska M, Lopez-Jaramillo P, Dans T, Langhorne P, Yusuf S; INTERSTROKE investigators. Rationale and design of INTERSTROKE: a global case-control study of risk factors for stroke. Neuroepidemiology. 2010;35(1):36-44. Epub 2010 Apr 8. PubMed PMID: 20389123. |
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Goyal A, Mehta SR, Díaz R, Gerstein HC, Afzal R, Xavier D, Liu L, Pais P, Yusuf S. Differential clinical outcomes associated with hypoglycemia and hyperglycemia in acute myocardial infarction. Circulation. 2009 Dec15; 120(24):2429-37. Epub PubMed PMID: 19948980. |
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Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, Pogue J, Reilly PA, Themeles E, Varrone J, Wang S, Alings M, Xavier D, Zhu J, Diaz R, Lewis BS, Darius H, Diener HC, Joyner CD, Wallentin L; RE-LY Steering Committee and Investigators. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009 Sep 17; 361(12):1139-51. Epub 2009 Aug 30. PubMed PMID: 19717844. |
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Goyal A, Mehta SR, Gerstein HC, Díaz R, Afzal R, Xavier D, Zhu J, Pais P, Lisheng L, Kazmi KA, Zubaid M, Piegas LS, Widimsky P, Budaj A, Avezum A, Yusuf S. Glucose levels compared with diabetes history in the risk assessment of patients with acute myocardial infarction. Am Heart J. 2009 Apr;157(4):763-70. Epub 2009 Feb 20. PubMed PMID: 19332208. |
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Xavier D, Pais P, Sigamani A, Pogue J, Afzal R, Yusuf S; Indian Polycap Study (TIPS) Investigators. The need to test the theories behind the Polypill: rationale behind the Indian Polycap Study. Nat Clin Pract Cardiovasc Med. 2009 Feb;6(2):96-7. Epub 2008 Dec 23. PubMed PMID: 19104516. |
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Diener HC, Sacco RL, Yusuf S, Cotton D, Ounpuu S, Lawton WA, Palesch Y, MartinRH, Albers GW, Bath P, Bornstein N, Chan BP, Chen ST, Cunha L, Dahlöf B, De Keyser J, Donnan GA, Estol C, Gorelick P, Gu V, Hermansson K, Hilbrich L, Kaste M, Lu C, Machnig T, Pais P, Roberts R, Skvortsova V, Teal P, Toni D, Vander Maelen C, Voigt T, Weber M, Yoon BW; Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study. Lancet Neurol. 2008 Oct;7(10):875-84. PubMed PMID: 18757238; PubMed Central PMCID: PMC2772657. |
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Yusuf S, Diener HC, Sacco RL, Cotton D, Ounpuu S, Lawton WA, Palesch Y, Martin RH, Albers GW, Bath P, Bornstein N, Chan BP, Chen ST, Cunha L, Dahlöf B, De Keyser J, Donnan GA, Estol C, Gorelick P, Gu V, Hermansson K, Hilbrich L, Kaste M, Lu C, Machnig T, Pais P, Roberts R, Skvortsova V, Teal P, Toni D, VanderMaelen C, Voigt T, Weber M, Yoon BW; PRoFESS Study Group. Telmisartan to prevent recurrent stroke and cardiovascular events. N Engl J Med. 2008 Sep 18;359(12):1225-37. Epub 2008 Aug 27. PubMed PMID: 18753639; PubMed Central PMCID: PMC2714258. |
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Sacco RL, Diener HC, Yusuf S, Cotton D, Ounpuu S, Lawton WA, Palesch Y, Martin RH, Albers GW, Bath P, Bornstein N, Chan BP, Chen ST, Cunha L, Dahlöf B, De Keyser J, Donnan GA, Estol C, Gorelick P, Gu V, Hermansson K, Hilbrich L, Kaste M, Lu C, Machnig T, Pais P, Roberts R, Skvortsova V, Teal P, Toni D, Vandermaelen C, Voigt T, Weber M, Yoon BW; PRoFESS Study Group. Aspirin and extended release dipyridamole versus clopidogrel for recurrent stroke. N Engl J Med. 2008 Sep 18;359(12):1238-51. Epub 2008 Aug 27. PubMed PMID: 18753638; PubMed Central PMCID: PMC2714259. |
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Devereaux PJ, Yang H, Yusuf S, Guyatt G, Leslie K, Villar JC, Xavier D, Chrolavicius S, Greenspan L, Pogue J, Pais P, Liu L, Xu S, Málaga G, Avezum A, Chan M, Montori VM, Jacka M, Choi P. Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial. Lancet. 2008 May 31;371(9627):1839-47. Epub 2008 May12. PubMed PMID: 18479744. |
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Xavier D, Devereaux PJ, Goyal A, Pais P, Yusuf S. Polypharmacotherapy for primary prevention of cardiovascular disease. Indian Heart J. 2008 Mar-Apr;60(2 Suppl B):B29-33. Review. PubMed PMID: 19359761. |
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Oldgren J, Wallentin L, Afzal R, Bassand JP, Budaj A, Chrolavicius S, Fox KA, Granger CB, Mehta SR, Pais P, Peters RJ, Xavier D, Zhu J, Yusuf S; OASIS-6 Investigators. Effects of fondaparinux in patients with ST-segment elevation acute myocardial infarction not receiving reperfusion treatment. Eur Heart J. 2008 Feb;29(3):315-23. Epub 2007 Dec 15. PubMed PMID: 18084015... |
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Cook D, Moore-Cox A, Xavier D, Lauzier F, Roberts I. Randomized trials in vulnerable populations. Clin Trials. 2008;5(1):61-9. PubMed PMID: 18283082. |
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Díaz R, Goyal A, Mehta SR, Afzal R, Xavier D, Pais P, Chrolavicius S, Zhu J, Kazmi K, Liu L, Budaj A, Zubaid M, Avezum A, Ruda M, Yusuf S. Glucose-insulin potassium therapy in patients with ST-segment elevation myocardial infarction. JAMA. 2007 Nov 28;298(20):2399-405. PubMed PMID: 18042917 |
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Karthikeyan G, Xavier D, Prabhakaran D, Pais P. Perspectives on the management of coronary artery disease in India. Heart. 2007 Nov;93(11):1334-8. Review. PubMed PMID: 17933988. |
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Mehta SR, Yusuf S, Díaz R, Zhu J, Pais P, Xavier D, Paolasso E, Ahmed R, Xie C, Kazmi K, Tai J, Orlandini A, Pogue J, Liu L; CREATE-ECLA Trial Group Investigators. Effect of glucose-insulin potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction: the CREATE-ECLA randomized controlled trial. JAMA. 2005 Jan 26;293(4):437-46. PubMed PMID:15671428. |
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Yusuf S, Mehta SR, Xie C, Ahmed RJ, Xavier D, Pais P, Zhu J, Liu L; CREATE Trial Group Investigators. Effects of reviparin, a low-molecular-weight heparin, on mortality, reinfarction, and strokes in patients with acute myocardial infarction presenting with ST-segment elevation. JAMA. 2005 Jan 26;293(4):427-35. PubMed PMID: 15671427. |
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Yusuf S, Mehta SR, Díaz R, Paolasso E, Pais P, Xavier D, Xie C, Ahmed RJ, Khazmi K, Zhu J, Liu L; CREATE-ECLA investigators and steering committee. Challenges in the conduct of large simple trials of important generic questions in resource-poor settings: the CREATE and ECLA trial program evaluating GIK (glucose, insulin and potassium) and low-molecular-weight heparin in acute myocardial infarction. Am Heart J. 2004 Dec;148(6):1068-78. PubMed PMID:15632895. |
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Hankey GJ, Algra A, Chen C, Wong MC, Cheung R, Wong L, Divjak I, Ferro J, de Freitas G, Gommans J, Groppa S, Hill M, Spence D, Lees K, Lisheng L, Navarro J, Ranawaka U, Ricci S, Schmidt R, Slivka A, Tan K, Tsiskaridze A, Uddin W, Vanhooren G, Xavier D, Armitage J, Hobbs M, Le M, Sudlow C, Wheatley K, Yi Q, Bulder M, Eikelboom JW, Hankey GJ, Ho WK, Jamrozik K, Klijn K, Koedam E, Langton P, Nijboer E, Tuch P, Pizzi J, Tang M, Antenucci M, Chew Y, Chinnery D, Cockayne C, Loh K, McMullin L, Smith F, Schmidt R, Chen C, Wong MC,de Freitas G, VITATOPS, the VITAmins TO prevent stroke trial: rationale and design of randomised trial of B-vitamin therapy in patients with recent transient ischaemic attack or stroke (NCT00097669) (ISRCTN74743444). Int J Stroke. 2007 May;2(2):144-50. PubMed PMID: 18705976. |
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Publications as Steering committee member/ collaborating site: |
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Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, McQueen M, Budaj A, Pais P, Varigos J, Lisheng L; INTERHEART Study Investigators. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet. 2004 Sep 11 17;364(9438):937-52. PubMed PMID: 15364185. |
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Mehta SR, Bassand JP, Chrolavicius S, Diaz R, Fox KA, Granger CB, Jolly S, Rupprecht HJ, Widimsky P, Yusuf S; CURRENT-OASIS 7 Steering Committee. Design and rationale of CURRENT-OASIS 7: a randomized, 2 x 2 factorial trial evaluating optimal dosing strategies for clopidogrel and aspirin in patients with ST and non-ST-elevation acute coronary syndromes managed with an early invasive strategy. Am Heart J. 2008 Dec;156(6):1080-1088.e1. Epub 2008 Nov 1. PubMed PMID:19033002. |
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Diener HC, Sacco R, Yusuf S; Steering Committee; PRoFESS Study Group. Rationale, design and baseline data of a randomized, double-blind, controlled trial comparing two antithrombotic regimens (a fixed-dose combination of extended-release dipyridamole plus ASA with clopidogrel) and telmisartan versus placebo in patients with strokes: the Prevention Regimen for Effectively Avoiding Second Strokes Trial (PRoFESS). Cerebrovasc Dis. 2007;23(5-6):368-80. Epub 2007Feb 26. Erratum in: Cerebrovasc Dis. 2008;25(1-2):192. PubMed PMID: 17337887. |
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Devereaux PJ, Yang H, Guyatt GH, Leslie K, Villar JC, Monteri VM, Choi P, Giles JW, Yusuf S. Rationale, design, and organization of the PeriOperative ISchemic Evaluation (POISE) trial: a randomized controlled trial of metoprolol versus placebo in patients undergoing noncardiac surgery. Am Heart J. 2006 Aug;152(2):223-30. PubMed PMID: 16875901. |
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Yusuf S, Mehta SR, Chrolavicius S, Afzal R, Pogue J, Granger CB, Budaj A, Peters RJ, Bassand JP, Wallentin L, Joyner C, Fox KA; OASIS-6 Trial Group. Effects of fondaparinux on mortality and reinfarction in patients with acute ST-segment elevation myocardial infarction: the OASIS-6 randomized trial. JAMA. 2006 Apr 5;295(13):1519-30. Epub 2006 Mar 14. PubMed PMID: 16537725. |
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MICHELANGELO OASIS 5 Steering Committee, Mehta SR, Yusuf S, Granger CB, Wallentin L, Peters RJ, Bassand JP, Budaj A, Joyner C, Chrolavicius S, Fox KA. Design and rationale of the MICHELANGELO Organization to Assess Strategies in Acute Ischemic Syndromes (OASIS)-5 trial program evaluating fondaparinux, a synthetic factor Xa inhibitor, in patients with non-ST-segment elevation acute coronary syndromes. Am Heart J. 2005 Dec;150(6):1107. PubMed PMID: 16338245. |
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Yusuf S, Hawken S, Ounpuu S, Bautista L, Franzosi MG, Commerford P, Lang CC, Rumboldt Z, Onen CL, Lisheng L, Tanomsup S, Wangai P Jr, Razak F, Sharma AM, Anand SS; INTERHEART Study Investigators. Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case control study. Lancet. 2005 Nov 5;366(9497):1640-9. PubMed PMID: 16271645. |
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