The Consortium on Vulnerability to Externalizing Disorders and Addictions (c-VEDA): an accelerated longitudinal cohort of children and adolescents in India

Authors : Zhang Y, Vaidya N, Iyengar U, Sharma E, Holla B, Ahuja CK, Barker GJ, Basu D, Bharath RD, Chakrabarti A, Desrivieres S, Elliott P, Fernandes G, Gourisankar A, Heron J, Hickman M, Jacob P, Jain S, Jayarajan D, Kalyanram K, Kartik K, Krishna M, Krishnaveni G, Kumar K, Kumaran K, Kuriyan R, Murthy P, Orfanos DP, Purushottam M, Rangaswamy M, Kupard SS, Singh L, Singh R, Subodh BN, Thennarasu K, Toledano M, Varghese M, Benegal V, Schumann G; c-VEDA consortium

Publication Year : 2020

Abstract :

The global burden of disease attributable to externalizing disorders such as alcohol misuse calls urgently for effective prevention and intervention. As our current knowledge is mainly derived from high-income countries such in Europe and North-America, it is difficult to address the wider socio-cultural, psychosocial context, and genetic factors in which risk and resilience are embedded in low- and medium-income countries. c-VEDA was established as the first and largest India-based multi-site cohort investigating the vulnerabilities for the development of externalizing disorders, addictions, and other mental health problems. Using a harmonised data collection plan coordinated with multiple cohorts in China, USA, and Europe, baseline data were collected from seven study sites between November 2016 and May 2019. Nine thousand and ten participants between the ages of 6 and 23 were assessed during this time, amongst which 1278 participants underwent more intensive assessments including MRI scans. Both waves of follow-ups have started according to the accelerated cohort structure with planned missingness design. Here, we present descriptive statistics on several key domains of assessments, and the full baseline dataset will be made accessible for researchers outside the consortium in September 2019. More details can be found on our website [].